George J. Seabury and Robert W. Johnson went their separate ways before the end of 1886. Seabury kept the name of Seabury & Johnson, while Johnson went into business with his brother, Edward M. Johnson, to form Johnson & Johnson. The new firm produced tooth powder, quinine pills, various plasters, and an antiseptic dressing.

Johnson & Johnson did not obtain a private die stamp until the autumn of 1899. These were produced with rouletting and hyphen-hole perforations, amounting to a total of 1,280,000 stamps. The one above has hyphen-hole perforations.

Note the similarities in design between the private die stamp above and the general issue "battleship" stamp below.

Johnson and Johnson used general issue proprietary stamps at the same time as the private die stamps, usually in different denominations. Rubber stamp cancels were used.

A 1901 cover addressed to Johnson and Johnson from the Meyer Brothers Drug Company of Saint Louis.