Hazeltine & Company began to produce Piso's Cure for Consumption in 1864. The name of the company was changed to E.T. Hazeltine in 1868.

The four-cent stamp was the first to be issued, in May of 1870. It was last issued February 12,1883. 119,706 were issued on old paper, 339,780 on silk paper and 116,840 on watermarked paper. The copy above is on silk paper.

The two-cent stamp was issued to be used with Piso's Remedy for Catarrh, from September, 1873 to October, 1876. 115,170 were printed on silk paper.

The one-cent stamps were the last to be issued. They were needed for Piso's Throat and Chest Salve, and were printed from sometime in 1878 to April 14, 1883. 1,002,020 were printed on watermarked paper.

A proof of the four cent issue.

After repeal of the tax on patent medicines as of July 1, 1883, Hazeltine used a facsimile. It was modeled on the one-cent private die stamp.

The company was incorporated in 1894 as The Piso Company. This facsimile label still claims that Piso's Remedy is a "cure" and may be from this period.

At some point there was a change to "remedy" in the facsimile label. It is unlikely that the claim would have gone from "remedy" to "cure" at any rate. Also, this stamp uses "Reg. U.S. Pat.Off." in the label, which may date it after the Spanish American War issues shown next.

When the War Revenue Act of 1898 reimposed taxes on proprietary medicines the Piso Company had the Bureau of Engraving and Printing make them a stamp. This one was perforated using rouletting.

Rouletting proved to cause problems in separating stamps, so the Bureau went to hyphen-hole perforations. These stamps illustrate that, as well as another issue. The odd denomination of 5/8's cent caused an odd number of stamps to be printed on a pane in order to have the cost come out in even cents. Hence the blank "stamp" in the lower right corner of this block.

After the end of the Spanish American War tax period, which should have been July 1, 1901 for domestic proprietary items, the Piso company again used facsimiles. These appear to have been printed directly on the box. The pure food and drug laws of 1906 reined in many of the claims for Piso's Remedies, but they remained in business well into the mid-1900's.

A post card advertising Piso's Cure. From the remark, "Nearly 50 Years the Favorite" it is likely to have been issued between March 1, 1907, when the back of post cards could be used for messages, and some time in 1914, when Piso's Cure would have been available for 50 years. The style of the back of the unsent card, with the wording "Postal Card," would suggest the earlier end of that range.